The Social Development Research Group (SDRG) at University of Washington (UW) will lead SAMHSA's Region 10 Northwest (NW) Prevention Technology Transfer Center (PTTC) in partnership with Washington State University (WSU), and the Center for the Application of Substance Abuse Technologies (CASAT) at the University of Nevada, Reno (UNR). NW PTTC partnering institutes share a vision to expand the impact of community activated prevention by equipping the prevention workforce with the power of prevention science. Every year, communities in Region 10 lose millions of dollars and thousands of bright futures to alcohol, cannabis, opioid misuse, violence and crime. The NW PTTC will serve as a primary training and technical assistance (TTA) resource to Region 10 by leveraging the knowledge of prevention science with the application of community capacity-building, workforce development, and expertise in knowledge transfer mechanisms.