The Northeast & Caribbean Prevention Technology Transfer Center (Northeast & Caribbean PTTC) is managed by the Rutgers Center for Prevention Science and serves New Jersey, New York, Puerto Rico, and the U.S. Virgin Islands. Its purpose is to strengthen the substance use prevention workforce through technology transfer activities, including the delivery of multifaceted training and technical assistance to improve knowledge and skills in prevention science and evidence-based prevention practices. The Northeast & Caribbean PTTC model includes federal, state, and local planning and capacity building; state-of-the-art training and technical assistance services; and prevention technology resources.