The Southeast Prevention Technology Transfer Center (Southeast PTTC) at Wake Forest School of Medicine is funded by the Substance Abuse Mental Health Services Administration (SAMHSA). We provide free, timely, high-quality training and technical assistance services to individuals and organizations in the substance misuse prevention field within Region 4 (Alabama, Florida, Georgia, Kentucky, Mississippi, North Carolina, South Carolina, and Tennessee). The Southeast PTTC provides diverse programming with multiple modes of training and technical assistance in the area of substance misuse prevention. We focus on capacity building and workforce development for the prevention field, the promotion of equity in all that we do, and support and guidance on the steps of local policy change. Our team has extensive experience in multiple areas of prevention, both in types of intervention strategies (e.g., environmental strategies) and populations served (e.g., communities of color; rural populations).