The Pacific Southwest Prevention Technology Transfer Center (PTTC) will provide training and technical assistance (TTA) services to the substance misuse prevention field in Region 9, encompassing American Samoa, Arizona, California, the Commonwealth of Northern Mariana Islands, Federated States of Micronesia, Guam, Hawaii, Nevada, Republic of the Marshall Islands, and the Republic of Palau. The overall goal is to advance Region 9's substance misuse prevention workforce's ability to identify, select, plan for, implement, and evaluate evidence-based and promising substance misuse prevention interventions to achieve a reduction in substance misuse and harmful consequences. This goal will be accomplished by strengthening regional alliances among culturally diverse prevention professionals and key partners, and delivering state-of-the-art, culturally-relevant TTA services that reflect regional and local needs.