Stimulant use can become a major substance use issue in the Central East region1 and nationwide. Usage has risen over the past several years, stimulants have become cheaper and more potent, and stimulant-involved overdoses have increased dramatically. The opioid epidemic remains the region's more significant public health crisis, but prevention professionals should address stimulants before trends worsen. This document highlights recent trends as well as the increased impact on the Central East and what prevention professionals can do.