Fentanyl is a powerful opioid analgesic – up to 100 times more potent than morphine. Although it may be legally prescribed to manage extreme pain, illicit use has increased dramatically since 2014. This product summarizes the scope and impact of fentanyl in the Central East region. It also provides recommendations for prevention and addiction professionals to help address the use and consequences of fentanyl, along with links to other resources to learn more.